Monthly Archives: July 2017

Clay Siegall sees precision medicine as being the undisputed future of medical treatments

The 20th century was a virtual miracle of scientific breakthroughs and medical treatments that gave people the ability to fight diseases in ways that were never before imagined. Even so, many of the greatest breakthroughs in medical science of the 20th century involved the use of means that, by the standards of today’s breakthroughs, would probably seem quite crude. Some of the largest gains in public health were made by such inventions as the smallpox vaccine, the polio vaccine and things like radiation therapy and the perfection of surgical excision techniques for cancers. These all tended to be fairly crude tools, which were used in a sort of one-size-fits-all method, with most patients, no matter the details of their illness, receiving more or less the same treatment.

But as the pace of innovation leading to huge gains in life expectancy that took place in medicine through the 1970s began to stagnate throughout the 80s and 90s, a new form of medicine began to take shape. Known as precision medicine, the idea behind this new discipline was that each patient and their circumstances can be very different. This means that physicians can find huge opportunities for maximizing individual patient outcomes, through the use of therapies that are specifically tailored to that patient or a cohort that shares certain characteristics.

Today, much precision medicine research revolves around the ability of modern science to sequence human genomes. But other types of precision medicine focus on different methods of creating tailor-made treatments for individual patient cohorts. One such example of the use of novel precision medicine techniques is the development of the class of drugs known as antibody drug conjugates. These drugs are largely the product of the life’s work of one man, Clay Siegall, co-founder of Seattle Genetics, the leading pharmaceutical company in the antibody drug conjugate space.

Dr. Siegall has been instrumental in creating this new and exciting form of targeted cancer therapy. By using human-like antibodies to deliver lethal cytotoxins directly to the site of malignancies, antibody drug conjugates are capable of increasing the amount of drug that can be safely administered to patients at any one sitting, by tens or even hundreds of times. This has made the treatment of certain cancers a virtual slam dunk.

Oncotarget and its Corresponding Fields of Research

Oncotarget is an open access medical journal that covers different aspects of oncology. It was first published in the year 2010 by the Impact Journals. It’s function is to publish papers online at a fee. Oncotarget’s mission is to come up with scientific results that are readily available. This is attained through intensive research to give room for further discovery. It is linked through their networks to different fields of study. Under the leadership of highly trained scientists, the journals aid researchers in contribution and the progress of science. The success of Oncotarget has led to the formation of sections beyond the field of oncology. Below are examples of further sections beyond oncology:

#1 Section on Pathology

Pathology section in Oncotarget was launched under the leadership of Michael Blagosklonny; who was the former Editor in Chief of American Journal of Pathology (AJP). The increasingly growing Oncotarget led to the formation of Pathology. There are several advantages of pathology section on Oncotarget as compared to ordinary pathology journals as shown below:

  • It has higher impact factor
  • Has relatively higher rapid publication
  • It is possible to submit papers rejected by other journal review platforms. Normally, it takes 1-5 days for the papers to be crosschecked.

#2 Sections on Aging (Gerotarget)

The section’s mandate is to publish high-end papers in different fields of researches related to; cellular senescence, pharmacological, signal transduction pathways, and genetics. The research also incorporates pathology model organisms in the treatment of age related diseases such as metabolic syndrome, hypertension, among others.

#3 Immunology and Microbiology Section

Success of Oncotarget has prompted the discovery of yet another section. The Immunology and Microbiology section deals in the publishing of papers in all areas in Oncotarget. Its specialty is research of cancer unrelated fields. Whereby, it incorporates the research of immunity cell development, antigen recognition, transplantation, clinical immunology, and mucosal immunology. Its submission is centralized via the Oncotarget systems. There are several advantages of this section as shown below:

  • Higher impact factor
  • Has relatively higher rapid publication
  • It is possible to communicate papers by the members of the Section Editorial Advisory Board

Could Kate Hudson’s Fabletics Really Close In On Amazon?

Amazon is not worried too often about another clothing company supposedly moving in on their profits. Amazon has been in complete cruise control in the fashion e-commerce market for many years, and not one of thousands of competitors have cut into the 20 percent they make of every sale in this market. Now before Amazon gets too comfortable, they may want to look closer at how Kate Hudson’s Fabletics has been gaining ground in the women’s clothing niche over the last three years. Sales figures are coming in at $250 million of women’s active-wear, something that should have Amazon at the least concerned.


When you talk to Hudson about how does her athleisure brand really connect with an audience, she credits things like membership perks and reverse showrooming as the two key components in the formula. Take a look at the workings inside the Fabletics retail store at the mall, you will discover that this is not your average clothes shopping experience. Inside the store, women are buying and window-shopping, trying on anything they can get their hands on, even taking a Fabletics lifestyle quiz to enhance the membership perks. There isn’t pressure from sales associates to buy, they are part of the overall soothing and relaxing atmosphere.


The reason that Kate Hudson’s Fabletics is gaining in the fashion e-commerce market comes down to the way women are shopping at the online store. If you’re a member and tried on clothing at the mall store, those items you like are uploaded to the membership account page at the online Fabletics store. The reason this is so beneficial is because now you just pick up and continue shopping exactly where you left off in the mall. When you are no longer concerned about how the clothing will fit because you were already wearing it in the mall, then these women are free to splurge on themselves.


The perks of being a Kate Hudson’s Fabletics member do not stop there. Membership entails free shipping for all those online orders, discounts on all active-wear, and your own shopping assistant. This personal shopper has one job, scan your quiz results, pick one item they think you will enjoy, drop it in the shopping cart for your consideration. If Amazon is not too concerned about the competition in that crowded marketplace, Kate Hudson’s Fabletics may be the company that finally gives them a real run for the money.

The World of Business with Eduardo Sirotsky Melzer (Duda Melzer)

Eduardo Sirotsky also known as Duda Melzer, is among the most successful individuals in Brazil. He is well known in Brazil and across the globe, as a result of his hard work and achievements in the business world. Duda is currently in charge of the RBS Company which was established by his grandfather. He comes from a family of entrepreneurs, and it is one of the major aspects that have contributed to his business success. The other factor contributing to his business achievement is that he did business administration up to the masters level (MBA) and he was committed to completing his studies since he knew the importance. Eduardo Sirotsky Melzer believes in family-run business activities as well as professional management which eventually leads to success.

When Eduardo was asked to mention some of the people who have had a positive impact in his business world apart from family, he mentioned Davis John. Check out Odiario for more info.

John is a professor at the Harvard University and specialist in the family business. Davis is also connected to the Eduardo Sirotsky Melzer for a long time since 1999 where the first encounter was in Brazil. The excellence rules for Davis in governance are effective and his team up with the Sirotsky family has created one of the most significant communication groups in Brazil. Apart from Davis, Eduardo mentions Ram Charan and Jim Collins as people who have also contributed to his success in the business world. He states that they are influential thinkers and have played a major role in the person he has become today. Check out Valor to know more.

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Psychotherapist Patty Rocklage: Uplifting The Community

Psychotherapist Patty Rocklage is an experienced and caring mental health professional who has been practicing successfully for more than twenty years. Her focus is on individual, marriage and family counseling with a desire to treat as many patients as she can. Read more: Pattry Rocklage | Crunchbase

Her solid reputation has made her a highly sought after therapist because she inspires trust and the ability to feel safe while in her care. Practicing in the greater Boston area, she has helped a great number of clients achieve personal healing. Her warm and caring personality has made it easy for people to open up to her.

Patty Rocklage received her professional degree in Psychology from the University of Southern California. She is married to notable chemistry scientist Scott Rocklage. Together they have donated to charitable causes, including a memorable donation of $250,000 to the Massachusetts Institute of Technology. The gift was given to MIT in thanks for providing Scott Rocklage with his education.

This generous donation from Patty and Scott Rocklage was earmarked for renovations to the chemistry and nanotech lab at the university. There will be a plaque with their names on it as a thank you for their amazing gift.

Patty Rocklage believes in connecting not just with her clients, but with the world to support her community. She is an impassioned volunteer for the Sudanese Education Fund, a non-profit organization that assists refugees from Sudan create a better life by helping them find viable educational options.

Patty’s team building skills, community outreach and public speaking skills add to the professional quality of her work. She is truly a dedicate psychotherapist who is making the world a better place.

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Sheldon Lavin: Leading A Food Business Empire

Sheldon Lavin is the chairman and chief executive officer of the OSI Group, LLC, one of the world’s largest suppliers of food products, food services and retail brands. He entered the industry more than 40 years ago, and has managed to grow the company exponentially and take it to where it currently is.

Sheldon Lavin previous job was an investor and a banking executive, and he also owns a financial consulting firm. However, he decided to challenge himself and entered an unfamiliar world, where he found himself working for a company focusing on supplying food products.


The company was still named Otto & Sons back in the 1970s, and it was the first time when Sheldon Lavin met them as he assisted the company with financing inquiries. During their early days, they managed to build a meat processing plant and became the largest supplier of hamburgers in the Midwest for McDonald’s Corporation; however, they needed funding so they seek the help of Sheldon Lavin who owns a financial consulting firm back then. The banks made an agreement that in order to secure funding for Otto & Sons, Sheldon Lavin should be given an ownership position. He initially declined the bank’s offer, but Sheldon Lavin soon accepted it when a new agreement was made where he would be given a financial investment that is in the same degree as the Otto family if he decided to become a partner.

At first, he is working indirectly with the company, but as the Otto patriarch decided to retire and left his sons to manage the company, Sheldon Lavin became more involved. McDonald’s have seen the potential of their partnership with Otto & Sons, so they decided to talk with Sheldon Lavin and persuaded him to work full time with the company. Otto & Sons became OSI Group, and the company began to expand, opening new offices overseas.

They started to operate across North America and have since made their presence felt in Europe, and they also made an expansion throughout South America and Asia during the the 1980’s. When the original owners decided to retire and sell their company shares, Sheldon Lavin took over. During his term as the company’s leader, he managed to strengthen the company’s ties with its partners, making it a successful corporation.

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Tips that Goettl Suspects you don’t know about keeping your HVAC in Perfect Condition

The comfort level that you will experience in your home depends on among other things, the type of HVAC you install and also its efficiency. As the surroundings become hotter and more humid, you will need the system to bring down the temperatures, clean up the dust in the air and keep the humidity levels down. When the system is not working properly, it ends up consuming too much electricity and with time, it might even crash altogether. It is therefore recommended that you take time and assess the system that you have for the sake of your comfort this season.

The first thing you need to check for is the SEER rating of the unit. The recommended SEER setting for a new system should be 13 and above. Anything below that means that the system is costing you more energy than it should. Goettl also states that old systems should have a rating of at least 9 because this is what will assure you of maximum efficiency.

Other tips that can help you succeed with your system include making sure it is always in the shade, applying window film to reduce the sun’s rays in the house, weatherizing your home into areas that need different temperature levels, cleaning and replacing the air filters and generally making sure that a system maintenance is run in the unit after every few months.

About Goettl

Goettl is one of the oldest and most reliable HVAC companies. The company is based in Phoenix Arizona but has branches in Las Vegas and other places. The current owner and CEO of the company, Ken Goodrich has really transformed the quality of the services they deliver to their clients.

He purchased the company because since childhood, he had always admired his father’s work in the HVAC industry. The company’s top values include tradition, quality service delivery to customers, honesty, reliability, innovation and attention to detail. The company is highly recommended by their clients.

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